2-((4-甲氧基苯基氨基)亚甲基)丙二酸二乙酯合成路线 （共 17 条）
反应条件
ethylenediamine in ethanol T=20°C; 0.333333 h;
参考文献
Ilangovan, Andivelu; Kumar, Rajendran Ganesh
Chemistry - A European Journal, 2010 , vol. 16, # 9 p. 2938 - 2943
反应条件
1: diphenyl ether biphenyl mixture 2: aqueous HCl 3: 275 °C View Scheme
参考文献
Ramsey; Cretcher
Journal of the American Chemical Society, 1947 , vol. 69, p. 1659,1660
反应条件
1: diphenyl ether biphenyl mixture 2: aqueous HCl View Scheme
参考文献
Schofield; Simpson
Journal of the Chemical Society, 1946 , p. 1033,1035
反应条件
in dowtherm A T=250°C; 1.5 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/2047 A2, 2006 ;
Location in patent: Page/Page column 60 ;
反应条件
1.1: Dowtherm™ A / 3 h / 250 °C 2.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C 3.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C 4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C 4.2: 2 h / 0 °C 5.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: diphenyl ether biphenyl mixture 2: aqueous NaOH 3: diphenyl ether / 245 °C 4: phosphoryl chloride; phosphorus (V)-chloride / 115 °C View Scheme
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
1.1: Dowtherm-A / ethanol / 250 - 260 °C 2.1: sodium hydroxide; hydrogenchloride / methanol / 2.5 °C / |Reflux 2.2: Dowtherm-A / 250 - 260 °C View Scheme
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
1: various solvent(s) / 1 h / Heating 2: aq. NaOH / 1 h / Heating View Scheme
参考文献
Golub, Andriy G.; Yakovenko, Olexander Ya.; Bdzhola, Volodymyr G.; Sapelkin, Vladislav M.; Zien, Piotr; Yarmoluk, Sergiy M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6443 - 6450
反应条件
1: With trichlorophosphate T=25 - 100°C; 5 h; Heating / reflux; 2: With sodium hydroxide in dichloromethane; water T=25 - 30°C; pH=7.5 - 8; 1.5 h;
参考文献
Aventis Pharma S.A.
Patent: US2005/182259 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: diphenyl ether biphenyl mixture 2: aqueous NaOH 3: diphenyl ether / 245 °C 4: phosphoryl chloride; phosphorus (V)-chloride / 115 °C 5: water; sulfuric acid View Scheme
参考文献
Ramsey; Cretcher
Journal of the American Chemical Society, 1947 , vol. 69, p. 1659,1660
