(2S,3aS,7aS)-八氢-1H-吲哚-2-羧酸苯甲酯合成路线 （共 7 条）
反应条件
1: With methanol; sodium hydroxide; water 2 h; Heating / reflux; 2: With hydrogenchloride; water in methanol pH=6 - 7;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2007/32661 A1, 2007 ;
Location in patent: Page/Page column 4 ;
反应条件
1: triethylamine / CH2Cl2 / 4 h / -15 - -10 °C 2: hydrogen / Pd/C View Scheme
参考文献
Synthetic Communications, , vol. 35, # 2 p. 243 - 248
反应条件
triethylamine in dichloromethane T=-15 - -10°C; 4 h;
参考文献
Singh, Girij Pal; Godbole, Himanshu M.; Nehate, Sagar P.; Mahajan, Pravin R.
Synthetic Communications, 2005 , vol. 35, # 2 p. 243 - 248
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in acetonitrile T=20°C; 0.5 h;
参考文献
WO2007/17087 A1, ;
Page/Page column 13 ;
反应条件
1: benzyl (S)-(S)-(S)-perhydroindole-2-carboxylate With triethylamine in dichloromethane T=25 - 39°C; 2: N-[1(S)-ethoxycarbonylbutyl]-(S)-alanine-2'-benzothiazolylthio ester in dichloromethane T=-15 - 30°C; 9 - 11 h; Product distribution / selectivity;
参考文献
WO2005/37788 A1, ;
Page/Page column 51 ;
反应条件
triethylamine in dichloromethane T=-15 - 30°C; 0.416667 - 0.5 h; Product distribution / selectivity;
参考文献
WO2005/37788 A1, ;
Page/Page column 47 ;
反应条件
triethylamine in dichloromethane T=-15 - -10°C; 4 h;
参考文献
Synthetic Communications, , vol. 35, # 2 p. 243 - 248
