1: t-BuOK / tetrahydrofuran / Ambient temperature 2: dimethylformamide / 80 °C 3: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 4: 68.7 percent / pyridine / 72 h / Ambient temperature 5: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 6: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 7: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 8: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: t-BuOK / tetrahydrofuran / Ambient temperature 2: dimethylformamide / 80 °C 3: 100 percent / pyridine / CHCl3 / 2 h / Ambient temperature 4: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 5: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature View Scheme

1: t-BuOK / tetrahydrofuran / Ambient temperature 2: dimethylformamide / 80 °C 3: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 4: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme