(4-氨基-苯基)-乙酸 甲酯 盐酸盐合成路线 （共 6 条）
反应条件
calcium carbonate in chloroform; water T=20°C; 16 h;
参考文献
Goodyer, Claire L. M.; Chinje, Edwin C.; Jaffar, Mohammed; Stratford, Ian J.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 19 p. 4189 - 4206
反应条件
thionyl chloride in methanol
参考文献
Karl Thomae
Patent: US5994356 A1, 1999 ;
反应条件
1: With water; tin(ll) chloride in ethyl acetate
48 h; Reflux;
2: With hydrogenchloride in diethyl ether
T=4°C;
参考文献
Kannan Sivaraman, Komagal; Paiardini, Alessandro; Sienczyk, Marcin; Ruggeri, Chiara; Oellig, Christine A.; Dalton, John P.; Scammells, Peter J.; Drag, Marcin; McGowan, Sheena
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5213 - 5217
反应条件
hydrogenchloride in methanol
参考文献
AtraZeneca AB
Patent: US2004/101864 A1, 2004 ;
反应条件
hydrogenchloride
4 h;
参考文献
Jacobson; Kirk; Padgett; Daly
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1341 - 1346
参考文献
AtraZeneca AB
Patent: US2004/101864 A1, 2004 ;
