(S)-2,3-二氢-1H-吡咯-1,2-二甲酸 1-叔丁基 2-甲基酯合成路线 （共 20 条）
反应条件
1: With lithium triethylborohydride in toluene T=-78°C; 1.16667 h; 2: With 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride in toluene T=20°C; 2 h;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
Location in patent: Paragraph 00348 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=80 - 90°C; 8 h;
参考文献
Synthesis, , # 9 p. 753 - 756
反应条件
1: With 2,6-dimethylpyridine; trifluoroacetic anhydride in toluene T=0°C; Acylation; 7 h; 2: Elimination; 0.333333 h; Heating;
参考文献
Oliveira, Denilson F.; Miranda, Paulo C. M. L.; Correia, Carlos R. D.
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6646 - 6652
反应条件
1: 93.8 percent / Ph3P, DEAD, CH3I / tetrahydrofuran / 10 h / Ambient temperature 2: 25 percent / DBU / toluene / 8 h / 80 - 90 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 1 p. 47 - 53
反应条件
T=170 - 180°C; P=12 Torr; 6 h;
参考文献
Angewandte Chemie, , vol. 92, # 9 p. 761
反应条件
in toluene 3 h; Heating;
参考文献
Synthesis, , # 9 p. 753 - 756
反应条件
1: 91 percent / Et3N / CH2Cl2 / 8 h / Ambient temperature 2: 93.8 percent / Ph3P, DEAD, CH3I / tetrahydrofuran / 10 h / Ambient temperature 3: 25 percent / DBU / toluene / 8 h / 80 - 90 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 1 p. 47 - 53
反应条件
1: 91 percent / Et3N / CH2Cl2 / 8 h / Ambient temperature 2: 93.8 percent / Ph3P, DEAD, CH3I / tetrahydrofuran / 10 h / Ambient temperature 3: 25 percent / DBU / toluene / 8 h / 80 - 90 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 1 p. 47 - 53
反应条件
1: SOCl2 / 8 h / Heating 2: 91 percent / Et3N / CH2Cl2 / 8 h / Ambient temperature 3: 93.8 percent / Ph3P, DEAD, CH3I / tetrahydrofuran / 10 h / Ambient temperature 4: 25 percent / DBU / toluene / 8 h / 80 - 90 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 1 p. 47 - 53
反应条件
1: m-chloroperoxybenzoic acid / CH2Cl2 / 0 °C 2: 9 percent / toluene / 3 h / Heating View Scheme
参考文献
Synthesis, , # 9 p. 753 - 756
