tin(IV) chloride in benzene 1.) 0 deg C, 20 min, 2.) room temperature, 2 h;

1: 51 percent / dimethylformamide / 24 h / 125 °C 2: 93 percent / Nh4Cl / ethanol / 24 h / Heating 3: 63 percent / LiOH / hexamethylphosphoric acid triamide / 24 h / Ambient temperature 4: 1.) H2, 2.) 6N HCl / 1.) 5percent Pd/C sulfided catalyst / 1.) EtOAc, 40 psi, 3 h, 2.) CH2Cl2, reflux, 2 h 5: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme

pyridine in methanol T=90°C; 48 h;

1: 63 percent / LiOH / hexamethylphosphoric acid triamide / 24 h / Ambient temperature 2: 1.) H2, 2.) 6N HCl / 1.) 5percent Pd/C sulfided catalyst / 1.) EtOAc, 40 psi, 3 h, 2.) CH2Cl2, reflux, 2 h 3: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme

1: 1.) H2, 2.) 6N HCl / 1.) 5percent Pd/C sulfided catalyst / 1.) EtOAc, 40 psi, 3 h, 2.) CH2Cl2, reflux, 2 h 2: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme

1: 93 percent / Nh4Cl / ethanol / 24 h / Heating 2: 63 percent / LiOH / hexamethylphosphoric acid triamide / 24 h / Ambient temperature 3: 1.) H2, 2.) 6N HCl / 1.) 5percent Pd/C sulfided catalyst / 1.) EtOAc, 40 psi, 3 h, 2.) CH2Cl2, reflux, 2 h 4: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme

暂无反应条件数据

1: diethyl ether 2: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme

1: 100 percent / KOH / methanol / Ambient temperature 2: dimethylformamide / 20 h / Heating 3: NH4OH, FeSO4 / H2O / 50 h / Heating 4: diethyl ether 5: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme

1: dimethylformamide / 20 h / Heating 2: NH4OH, FeSO4 / H2O / 50 h / Heating 3: diethyl ether 4: 92 percent / SnCl4 / benzene / 1.) 0 deg C, 20 min, 2.) room temperature, 2 h View Scheme