6-(三氟甲基)-2(1H)-喹啉酮合成路线 (共 5 条)
反应条件
hydrogenchloride in 1,4-dioxane
T=100°C;
参考文献
ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely
Patent: WO2010/91310 A1, 2010 ;
Location in patent: Page/Page column 185 ;
WO 2010/091310 A1
反应条件
hydrogenchloride in tetrahydrofuran
Heating;
参考文献
Knight, Roland L.; Allen, Daniel R.; Birch, Helen L.; Chapman, Gayle A.; Galvin, Frances C.; Jopling, Louise A.; Lock, Christopher J.; Meissner, Johannes W.G.; Owen, David A.; Raphy, Gilles; Watson, Robert J.; Williams, Sophie C.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 629 - 633
反应条件
1: pyridine / dichloromethane / 4 h / 0 - 20 °C
2: sulfuric acid / 2 h / 0 °C
View Scheme
参考文献
Merial Limited; Meng, Charles Q.; Long, Alan; Huber, Scot; Gurrala, Srinivas Reddy; Wilkinson, Douglas Edward; Pacofsky, Gregory
Patent: US2014/142114 A1, 2014 ;
反应条件
trichlorophosphate
T=110°C; 2 h;
参考文献
Knight, Roland L.; Allen, Daniel R.; Birch, Helen L.; Chapman, Gayle A.; Galvin, Frances C.; Jopling, Louise A.; Lock, Christopher J.; Meissner, Johannes W.G.; Owen, David A.; Raphy, Gilles; Watson, Robert J.; Williams, Sophie C.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 629 - 633
反应条件
1: trichlorophosphate / 2 h / 110 °C
2: ammonium hydroxide / 130 °C
View Scheme
参考文献
Merial Limited; Meng, Charles Q.; Long, Alan; Huber, Scot; Gurrala, Srinivas Reddy; Wilkinson, Douglas Edward; Pacofsky, Gregory
Patent: US2014/142114 A1, 2014 ;