1-(2-(4-溴苯氧基)乙基)哌啶合成路线 （共 4 条）
反应条件
caesium carbonate; potassium iodide in N,N-dimethyl-formamide T=25 - 50°C; 14.5 h;
参考文献
Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003
反应条件
di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine in tetrahydrofuran T=0 - 20°C; 7 h;
参考文献
NOVACEA, INC.
Patent: WO2007/98090 A2, 2007 ;
Location in patent: Page/Page column 62; 65 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -76 - -73 °C / |Inert atmosphere
1.2: 8 h / -78 °C / |Inert atmosphere
2.1: hydrogenchloride / dichloromethane / 0.75 h / 10 - 15 °C / |Inert atmosphere
View Scheme
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Youells, Scott; Beish, Sandra; Hu, Zhiyong; Branum, Shawn; Jain, Nareshkumar; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 731 - 738
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -76 - -73 °C / |Inert atmosphere
1.2: 2.33 h / -73 °C / |Inert atmosphere
2.1: hydrogenchloride / water / 0.75 h / 10 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Youells, Scott; Beish, Sandra; Hu, Zhiyong; Branum, Shawn; Jain, Nareshkumar; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 731 - 738
