(R)-3-氨基-3-苯基丙酸盐酸盐合成路线 （共 7 条）
反应条件
penicillin G acylase; Eupergit in ethanol; water 4 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
反应条件
hydrogenchloride in water
参考文献
Journal of the American Chemical Society, , vol. 132, # 2 p. 464 - 465
反应条件
1: 75 percent / Et3N / acetone; H2O / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 2: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
反应条件
1: 75 percent / ammonium acetate / ethanol / 6 h / Heating 2: 75 percent / Et3N / acetone; H2O / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 3: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 167 - 174
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 167 - 174
反应条件
1: 0.75 g / Et3N / acetone / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 2: SOCl2 / Ambient temperature 3: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 4: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Cardillo; Gentilucci; Tolomelli; Tomasini
Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2351 - 2353
