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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
836633-05-7
合成路线
(共 5 条)
836633-15-9
→
反应条件
836633-05-7
反应条件
1: With AlCl3, aluminium chloride in toluene 0.666667 h; Heating / reflux; 2: With sodium hydroxide; water 0.5 h; 3: With hydrogenchloride in water T=28°C; pH=2; 0.5 h;
参考文献
Aventis Pharma S.A.
Patent: US2005/26984 A1, 2005 ;
Location in patent: Page 6 ;
873072-59-4
→
反应条件
836633-05-7
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Akritopoulou-Zanze, Irini; Darczak, Daria; Sarris, Kathy; Phelan, Kathleen M.; Huth, Jeffrey R.; Song, Danying; Johnson, Eric F.; Jia, Yong; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 96 - 99
873072-57-2
→
反应条件
836633-05-7
反应条件
1: 44 percent / NaOH / methanol / 50 °C 2: 99 percent / HCl / dioxane View Scheme
参考文献
Akritopoulou-Zanze, Irini; Darczak, Daria; Sarris, Kathy; Phelan, Kathleen M.; Huth, Jeffrey R.; Song, Danying; Johnson, Eric F.; Jia, Yong; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 96 - 99
94-02-0
苯甲酰乙酸乙酯
→
反应条件
836633-05-7
反应条件
1.1: hydrazine hydrate; AcOH / ethanol / 2 h / 90 °C 2.1: POCl3 / Heating 2.2: Et3N / tetrahydrofuran / 20 °C 3.1: Na2CO3 / methanol / Heating 4.1: 44 percent / NaOH / methanol / 50 °C 5.1: 99 percent / HCl / dioxane View Scheme
参考文献
Akritopoulou-Zanze, Irini; Darczak, Daria; Sarris, Kathy; Phelan, Kathleen M.; Huth, Jeffrey R.; Song, Danying; Johnson, Eric F.; Jia, Yong; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 96 - 99
4860-93-9
1,2-二氢-5-苯基吡唑-3-酮
→
反应条件
836633-05-7
反应条件
1.1: POCl3 / Heating 1.2: Et3N / tetrahydrofuran / 20 °C 2.1: Na2CO3 / methanol / Heating 3.1: 44 percent / NaOH / methanol / 50 °C 4.1: 99 percent / HCl / dioxane View Scheme
参考文献
Akritopoulou-Zanze, Irini; Darczak, Daria; Sarris, Kathy; Phelan, Kathleen M.; Huth, Jeffrey R.; Song, Danying; Johnson, Eric F.; Jia, Yong; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 96 - 99