7-氯-4-(1-哌嗪基)喹啉合成路线 (共 3 条)
反应条件
triethylamine T=130°C; 4 h; Inert atmosphere;
参考文献
Youngsaye, Willmen; Vincent, Benjamin; Hartland, Cathy L.; Morgan, Barbara J.; Buhrlage, Sara J.; Johnston, Stephen; Bittker, Joshua A.; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L.; Munoz, Benito
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5502 - 5505
反应条件
sodium carbonate in water T=100°C; 15 h;
参考文献
MATRIX LABORATORIES LTD.; SETHI, Madhuresh, Kumar; RAWAT, Vijendra, Singh; AYYARAN, Karthikeyan; YERRAMALLA, Raja, Krishna; BONTALAKOTI, Jagan, Mohan, Rao; VEMULA, Lakshminarayana; NIMMAGADDA, Anitha; DATTA, Debashish
Patent: WO2011/95885 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
triethylamine in dichloromethane
T=0 - 20°C;
参考文献
Salahuddin, Attar; Inam, Afreen; Van Zyl, Robyn L.; Heslop, Donovan C.; Chen, Chien-Teng; Avecilla, Fernando; Agarwal, Subhash M.; Azam, Amir
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 3080 - 3089