N,N-二甲基-2-((4'-(噻吩-2''-基)嘧啶-2'-基)硫代)乙胺合成路线 （共 3 条）
反应条件
1: 2-dimethylaminoethylmercaptan hydrochloride With sodium ethanolate
T=20°C; 0.25 h;
2: 2-chloro-4-(thiophen-2-yl)pyrimidine T=70°C; 12 h; Further stages.;
参考文献
Bello, Angelica M.; Bende, Tanushree; Wei, Lianhu; Wang, Xiaoyang; Majchrzak-Kita, Beata; Fish, Eleanor N.; Kotra, Lakshmi P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 9 p. 2734 - 2743
反应条件
sodium hydride in tetrahydrofuran
T=20°C; Condensation;
参考文献
Chou, Yi-Meen; Lai, Ming Chih; Hwang, Tsai-Mian; Ong, Chi Wi
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 18 p. 2643 - 2646
反应条件
n-butyllithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone
1.) ether, -40 deg C, 15 min; -10 deg C, 30 min, 2.) THF, 25 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Strekowski, Lucjan; Mokrosz, Jerzy L.; Tanious, Farial A.; Watson, Rebecca A.; Harden, Donald; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1231 - 1240
