sodium hydroxide T=60 - 70°C; 3 h;

1: aq. NaOH / 3 h / 60 - 70 °C 2: Et3N / dimethylformamide / 1 h / Ambient temperature 3: dimethylformamide / 3 h / Ambient temperature 4: 91 percent / H2 / 10 percent Pd-C / ethanol; H2O / 45 - 50 °C View Scheme