2-(溴甲基)-1-氯-3-甲氧基苯合成路线 （共 3 条）
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in tetrachloromethane
12 h; Heating;
参考文献
Ito; Nakatsuka; Saegusa
Journal of the American Chemical Society, 1982 , vol. 104, # 26 p. 7609 - 7622
反应条件
phosphorus tribromide in dichloromethane
T=-10 - 5°C; 6.66667 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; ALLEN, David, George; COE, Diane, Mary; COOPER, Anthony, William, James; GORE, Paul, Martin; HOUSE, David; SENGER, Stefan; SOLLIS, Steven, Leslie; VILE, Sadie; WILSON, Caroline
Patent: WO2010/122089 A1, 2010 ;
Location in patent: Page/Page column 58 ;
反应条件
1: 85 percent / ethanol; H2O / 0.25 h / Ambient temperature
2: 80 percent / benzene; diethyl ether / 36 h / Ambient temperature
3: 97 percent
4: CsF / acetonitrile / 1 h / Ambient temperature
View Scheme
参考文献
Ito; Nakatsuka; Saegusa
Journal of the American Chemical Society, 1982 , vol. 104, # 26 p. 7609 - 7622
