1-(4-氟苯基甲基)-2-氨基苯并咪唑合成路线 （共 13 条）
反应条件
hydrogenchloride; sodium hydroxide in chloroform; water; N,N-dimethyl-formamide
参考文献
Janssen Pharmaceutica N.V.
Patent: US4988689 A1, 1991 ;
反应条件
hydrogenchloride in methanol T=20°C; 2 h; Irradiation;
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
hydrogen bromide in methanol; water T=20°C; 2 h; Irradiation;
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
potassium hydroxide in acetone T=20°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 9 p. 1080 - 1083
反应条件
phosphoric acid T=20°C; 2 h; Irradiation;
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 14 h / 0 - 65 °C / Inert atmosphere 2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere 2.2: 3.5 h / -78 - 20 °C / Inert atmosphere 3.1: hydrogenchloride / methanol / 2 h / 20 °C / Irradiation View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 14 h / 0 - 65 °C / Inert atmosphere 2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere 2.2: 3.5 h / -78 - 20 °C / Inert atmosphere 3.1: hydrogen bromide / methanol; water / 2 h / 20 °C / Irradiation View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 14 h / 0 - 65 °C / Inert atmosphere 2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere 2.2: 3.5 h / -78 - 20 °C / Inert atmosphere 3.1: phosphoric acid / 2 h / 20 °C / Irradiation View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere 1.2: 3.5 h / -78 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / methanol / 2 h / 20 °C / Irradiation View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
反应条件
1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere 1.2: 3.5 h / -78 - 20 °C / Inert atmosphere 2.1: hydrogen bromide / methanol; water / 2 h / 20 °C / Irradiation View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 681 - 684
