2-正丁基-4-氯-5-甲酰基咪唑合成路线 （共 45 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; N-chloro-succinimide; sodium hydrogencarbonate in water; toluene T=20°C;
参考文献
Miller, Ross A; Hoerrner, R Scott
Organic letters, 2003 , vol. 5, # 3 p. 285 - 287
反应条件
1.1: HCl / 12 h / 20 °C 1.2: aq. KOH / toluene / 5 °C 2.1: aq. KOH / toluene; methanol / 15 h / 40 °C 3.1: 132 g / POCl3 / toluene / 3 h / 97 - 100 °C View Scheme
参考文献
Synthesis, , # 4 p. 506 - 508
反应条件
1: aq. KOH / toluene; methanol / 15 h / 40 °C 2: 132 g / POCl3 / toluene / 3 h / 97 - 100 °C View Scheme
参考文献
Synthesis, , # 4 p. 506 - 508
反应条件
trichlorophosphate in chlorobenzene T=100°C; Formylation; Vilsmeier reaction; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8084 - 8089
反应条件
2: 44 percent / CH2Cl2 / 20 - 27 °C 3: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8084 - 8089
反应条件
1: 44 percent / CH2Cl2 / 20 - 27 °C 2: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8084 - 8089
反应条件
hydrogenchloride 24 h; Heating;
参考文献
Watson
Synthetic Communications, 1992 , vol. 22, # 20 p. 2971 - 2977
反应条件
1: 40 percent / 24 h / -10 °C 2: 44 percent / CH2Cl2 / 20 - 27 °C 3: 88 percent / POCl3 / 1.5 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8084 - 8089
反应条件
1: H2O 2: MnO2 / CH2Cl2 3: N-chlorosuccinimide View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
1: Et3N / chlorobenzene / Heating 2: H2O / Acid hydrolysis View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 22 p. 8084 - 8089
