1: N-[(4-chlorophenyl)phenylmethyl]piperazine With tetrabutylammomium bromide; potassium carbonate in water T=25°C; 2: 2-(2-chloroethoxy)acetamide in water T=80°C;
1: With thionyl chloride in N,N-dimethyl-formamide T=20°C; 3 h; Large scale; 2: With ammonia in N,N-dimethyl-formamide; toluene T=0 - 30°C; Large scale;
参考文献
Organic Process Research and Development, , vol. 5, # 2 p. 110 - 115
