hydrogenchloride in water; acetone T=20 - 50°C; 2 h;

1: With sodium hydroxide in water; dimethyl sulfoxide; toluene T=30 - 35°C; 14 - 18 h; 2: With hydrogenchloride in water; acetone T=20°C;

1: With sodium hydroxide in water Heating / reflux; 2: With hydrogenchloride in ethyl acetate; isopropyl alcohol 1 - 2 h;

ammonium hydroxide; sodium hydroxide; sodium carbonate in N-methyl-acetamide; hydrogenchloride; acetone

in 1,4-dioxane

in 1,4-dioxane

暂无反应条件数据

1.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction 2.1: toluene / 3 h / 80 °C / Large scale reaction 2.2: pH 1 / Large scale reaction 3.1: water / toluene 4.1: sodium methylate / toluene / 10 - 15 °C / Inert atmosphere; Large scale reaction 4.2: 2 h / 50 - 60 °C / Large scale reaction 5.1: water; sodium hydroxide / 3 h / Reflux; Large scale reaction View Scheme

1.1: toluene / 3 h / 80 °C / Large scale reaction 1.2: pH 1 / Large scale reaction 2.1: water / toluene 3.1: sodium methylate / toluene / 10 - 15 °C / Inert atmosphere; Large scale reaction 3.2: 2 h / 50 - 60 °C / Large scale reaction 4.1: water; sodium hydroxide / 3 h / Reflux; Large scale reaction View Scheme

1.1: sodium methylate / toluene / 10 - 15 °C / Inert atmosphere; Large scale reaction 1.2: 2 h / 50 - 60 °C / Large scale reaction 2.1: water; sodium hydroxide / 3 h / Reflux; Large scale reaction View Scheme