3-羟基-4,4-二甲氧基-1-哌啶羧酸乙酯合成路线 (共 4 条)
反应条件
potassium hydroxide; iodine
T=0 - 20°C; 6.25 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2009/33581 A1, 2009 ;
Location in patent: Page/Page column 77-78 ;
反应条件
sodium methylate in methanol; di-isopropyl ether
参考文献
Janssen Pharmaceutica N.V.
Patent: US4962115 A1, 1990 ;
反应条件
sodium iodide in methanol
T=30°C; Electrochemical reaction;
参考文献
Elinson, Michail N.; Dorofeev, Alexander S.; Feducovich, Sergey K.; Nasybullin, Ruslan F.; Litvin, Evgeny F.; Kopyshev, Mikhail V.; Nikishin, Gennady I.
Tetrahedron, 2006 , vol. 62, # 34 p. 8021 - 8028
反应条件
in N,N-dimethyl-formamide
参考文献
Janssen Pharmaceutica N.V.
Patent: US4962115 A1, 1990 ;