4-(氰基甲基)苯甲酸乙酯合成路线 （共 10 条）
反应条件
1: Nitrierung 2: palladium/charcoal; ethyl acetate / Hydrogenation View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 4622,4624
反应条件
1: With sodium hydroxide; ethanol; water 1 h; Heating / reflux; 2: With hydrogenchloride; water T=0°C;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 35 ;
反应条件
Josiphos Et2P-Fc-PtBu2 ligand; sodium acetate; palladium diacetate
T=130 - 135°C; P=2068.59 Torr; 20 h;
参考文献
Cai, Chaoxian; Rivera, Nelo R.; Balsells, Jaume; Sidler, Rick R.; McWilliams, J. Christopher; Shultz, C. Scott; Sun, Yongkui
Organic Letters, 2006 , vol. 8, # 22 p. 5161 - 5164
反应条件
tris(dibenzylideneacetone)dipalladium (0); ZnF2; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide
T=90°C; 8 h;
参考文献
Wu, Lingyun; Hartwig, John F.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15824 - 15832
反应条件
in ethanol; water
T=20°C; 15 h; Heating / reflux;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 34 ;
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; bis(η3-allyl-μ-chloropalladium(II)) in 1,3,5-trimethyl-benzene
T=20 - 140°C; 5.16667 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Shang, Rui; Ji, Dong-Sheng; Chu, Ling; Fu, Yao; Liu, Lei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 19 p. 4470 - 4474
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; water in dimethyl sulfoxide
T=130°C; Domino Suzuki coupling and fragmentation reaction; 16 h; Inert atmosphere;
参考文献
Velcicky, Juraj; Soicke, Arne; Steiner, Roland; Schmalz, Hans-Guenther
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6948 - 6951
参考文献
Snyder et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 4622,4624
反应条件
1: dibenzoyl peroxide; CCl4; N-bromo-succinimide
2: KCN
View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 4622,4624
反应条件
1: aq. HCl / 1.5 h / 20 - 23 °C
2: aq. NaNO2, HCl / 2 h / 35 °C
View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
