4-(甲氧基甲基)-6-(苯基甲氧基)-9h-吡啶并[3,4-b]吲哚-3-羧酸乙酯盐酸盐合成路线 （共 8 条）
反应条件
1.1: acetic acid / toluene / 4 h / Heating
2.1: 8.1 g / hydrogen / Raney nickel / ethanol / 6 h / 1900 Torr
3.1: ethyl acetate; H2O / 20 °C
3.2: Pd/C / xylene / Heating
View Scheme
参考文献
Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P.
Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307
反应条件
1.1: 8.1 g / hydrogen / Raney nickel / ethanol / 6 h / 1900 Torr
2.1: ethyl acetate; H2O / 20 °C
2.2: Pd/C / xylene / Heating
View Scheme
参考文献
Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P.
Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307
反应条件
sulfur in dimethyl sulfoxide
T=144°C; 1 h; Heating; Yield given;
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1.1: acetic acid / toluene / 4 h / Heating
2.1: 8.1 g / hydrogen / Raney nickel / ethanol / 6 h / 1900 Torr
3.1: ethyl acetate; H2O / 20 °C
3.2: Pd/C / xylene / Heating
View Scheme
参考文献
Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P.
Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307
反应条件
1: 87 percent / 10percent aq. K2CO3 / ethyl acetate / 16 h / Ambient temperature
2: xylene / 1 h / Heating
3: sulfur / dimethylsulfoxide / 1 h / 144 °C / Heating
View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: xylene / 1 h / Heating
2: sulfur / dimethylsulfoxide / 1 h / 144 °C / Heating
View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: in water; ethyl acetate
T=20°C; Condensation; decarboxylation;
2: With palladium on activated charcoal in xylene
Dehydrogenation; Heating; Title compound not separated from byproducts;
参考文献
Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P.
Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307
反应条件
1: 62 percent / Pd(OAc)2; PPh3; n-Bu3N / dimethylformamide / 100 °C
2: 80 percent / aq. HCl / ethanol / 24 h / 70 °C
View Scheme
参考文献
Zhang, Haiming; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9318 - 9330
