2-氯-联苯-4-羧酸乙酯合成路线 (共 2 条)
反应条件
1: With sodium hydroxide; water in methanol T=20°C; 6 h; 2: With hydrogenchloride in methanol; water
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2003/97617 A1, 2003 ;
Location in patent: Page/Page column 47 ;
WO 03/097617 A1
反应条件
1: 4-bromo-benzoic acid ethyl ester With tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene
T=20°C; 0.333333 h;
2: 2-Chlorophenyl-dihydroxyborane With potassium carbonate in ethanol; toluene
T=70°C; 6 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2003/97617 A1, 2003 ;
Location in patent: Page/Page column 47 ;
WO 03/097617 A1