N-Boc-3-氨基丙基溴合成路线 （共 24 条）
反应条件
1: 91 percent / DEAD, PPh3 / tetrahydrofuran / 16 h / Ambient temperature 2: LiOH / tetrahydrofuran; H2O / 3 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 45 p. 8275 - 8276
反应条件
lithium hydroxide in tetrahydrofuran; water 3 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 39, # 45 p. 8275 - 8276
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 20 h; chemoselective reaction;
参考文献
Everson, Daniel A.; Jones, Brittany A.; Weix, Daniel J.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6146 - 6159
反应条件
in tetrahydrofuran T=20°C; 4 h;
参考文献
KALYPSYS, INC.
Patent: US2007/123572 A1, 2007 ;
Location in patent: Page/Page column 16 ;
反应条件
1: N-(tert-butoxycarbonyl)-3-bromopropylamine With nickel(II) bromide trihydrate; bathophenanthroline in N,N-dimethyl-formamide T=40°C; 0.333333 h; 2: alpha-chloropyridine With manganese in N,N-dimethyl-formamide T=40°C; Sealed tube;
参考文献
Everson, Daniel A.; Buonomo, Joseph A.; Weix, Daniel J.
Synlett, 2014 , vol. 25, # 2 art. no. ST-2013-R0770-L, p. 233 - 238
反应条件
sodium iodide in acetone T=20°C; 16 h;
参考文献
Wescott, Lyle D.; Mattern, Daniell Lewis
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10058 - 10066
反应条件
manganese; [NiCl2(1,2-dimethoxyethane)]; Ru(4,4′,4''-tri-t-butyl-2,2′;6,2″-terpyridine)Cl3 in N,N-dimethyl-formamide T=40°C; 24 h;
参考文献
Prinsell, Michael R.; Everson, Daniel A.; Weix, Daniel J.
Chemical Communications, 2010 , vol. 46, # 31 p. 5743 - 5745
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 20 h; chemoselective reaction;
参考文献
Everson, Daniel A.; Jones, Brittany A.; Weix, Daniel J.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6146 - 6159
反应条件
1: 60 percent / KF/Celite / acetonitrile / 1.) RT, 16 h, 2.) 70 deg C, 24 h
2: 96 percent / CH2Cl2 / 68 h / Ambient temperature
3: 95 percent / H2 / Pd(OH)2/C / acetic acid / 2 h / 2585.7 Torr
View Scheme
参考文献
Jasys, V. John; Kelbaugh, Paul B.; Nason, Deane M.; Phillips, Douglas; Rosnack, Kenneth J.; Saccomano, Nicholas A.; Stroh, Justin G.; Volkmann, Robert A.
Journal of the American Chemical Society, 1990 , vol. 112, # 18 p. 6696 - 6704
反应条件
1: tert-butylamine With cesium hydroxide in N,N-dimethyl-formamide
T=20°C; 0.5 h; Molecular sieve;
2: N-(tert-butoxycarbonyl)-3-bromopropylamine in N,N-dimethyl-formamide
T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/27211 A1, 2006 ;
Location in patent: Page/Page column 65-66 ;
WO 2006/027211 A1
