5-(T-boc-氨基)-1-戊基溴合成路线 （共 10 条）
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=0 - 20°C;
参考文献
MYREXIS, INC.; KUMAR, Dange Vijay; SLATTUM, Paul M.; YAGER, Kraig M.; SHENDEROVICH, Mark D.; TANGALLAPALLY, Rajendra; KIM, Se-Ho
Patent: WO2012/177782 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/177782 A1
反应条件
lithium hydroxide in tetrahydrofuran; water T=20°C; 3 h;
参考文献
Lee, Kangwon; Rouillard, Jean-Marie; Pham, Trinh; Gulari, Erdogan; Kim, Jinsang
Angewandte Chemie - International Edition, 2007 , vol. 46, # 25 p. 4667 - 4670
反应条件
1: 99 percent / Et3N / H2O; acetonitrile / 16 h / 25 °C / pH 12 2: 52 percent / Ph3P; NBS; pyridine / CH2Cl2 / 8 h / 25 °C View Scheme
参考文献
Carbohydrate Research, , vol. 322, # 3-4 p. 201 - 208
反应条件
sodium hydroxide in dichloromethane; water
参考文献
Henig, Joerg; Mamedov, Ilgar; Fouskova, Petra; Toth, Eva; Logothetis, Nikos K.; Angelovski, Goran; Mayer, Hermann A.
Inorganic Chemistry, 2011 , vol. 50, # 14 p. 6472 - 6481
反应条件
1: 81 percent / potassium tert-butoxide / dimethylformamide / 1 h / 60 °C 2: 83 percent / LiOH / H2O; tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 46, # 25 p. 4667 - 4670
反应条件
tetrabutylammomium bromide; sodium bromide in acetonitrile Reflux;
参考文献
Yoo, Barney; Cheal, Sarah M.; Torchon, Geralda; Dilhas, Anna; Yang, Guangbin; Pu, Jun; Punzalan, Blesida; Larson, Steven M.; Ouerfelli, Ouathek
Bioconjugate Chemistry, 2013 , vol. 24, # 12 p. 2088 - 2103
参考文献
Manzo, Emiliano; Pagano, Dario; Carbone, Marianna; Ciavatta, M. Letizia; Gavagnin, Margherita
Arkivoc, 2012 , vol. 2012, # 9 p. 220 - 228
反应条件
1: 92 percent / acetonitrile / 24 h / Ambient temperature 2: 78 percent / PPh3, CBr4 / tetrahydrofuran / Ambient temperature; 1.) 2 h, 2.) stirring overnight View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, p. 24
反应条件
1: BH3 / tetrahydrofuran / 1 h 2: Ph3P, CBr4 / tetrahydrofuran; acetonitrile / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
反应条件
1: 62 percent / KI, K2CO3 / acetone / 24 h / Heating
2: 92 percent / CF3COOH / 0.25 h / Ambient temperature
3: 95.6 percent / Et3N / acetonitrile / 2.5 h / Ambient temperature
4: tetrahydrofuran; H2O / 2 h
5: H2 / 5percent Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
