4-甲基-4-苯基哌啶盐酸盐合成路线 （共 3 条）
反应条件
1: With ammonium formate; palladium 10 on activated carbon in industrial methylated spirit; water
0.5 h; RefluxInert atmosphere;
2: With hydrogenchloride in 1,4-dioxane
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
Location in patent: Page/Page column 64 ;
WO 2011/033255 A1
反应条件
1: diethyl ether / 1.5 h / -78 °C
2: AlCl3, aluminium chloride / 62 h / 20 - 100 °C
3: ammonium formate / palladium 10 on activated carbon / water; industrial methylated spirit / 0.5 h / Reflux; Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
WO 2011/033255 A1
反应条件
1: AlCl3, aluminium chloride / 62 h / 20 - 100 °C
2: ammonium formate / palladium 10 on activated carbon / water; industrial methylated spirit / 0.5 h / Reflux; Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
WO 2011/033255 A1
