1: 70 percent / TsOH / acetonitrile 2: 53 percent / Hg(CN)2, HgBr2 / nitromethane; toluene 3: 95 percent / H2 / 9.7percent Pd-C / acetic acid; methanol / 18 h / Ambient temperature 4: 87 percent / NaOMe/MeOH / 0 °C View Scheme