4,4,4-三氟-2-(三苯基正膦亚基)乙酰乙酸乙酯合成路线 （共 5 条）
参考文献
Chen, Jian; Lin, Guo-Qiang; Wang, Zhi-Min; Liu, Han-Quan
Synlett, 2002 , # 8 p. 1265 - 1268
反应条件
1: (ethoxycarbonylmethyl)-triphenylphosphonium bromide With triethylamine in tetrahydrofuran
T=2°C; 0.5 h;
2: trifluoroacetic anhydride in tetrahydrofuran
2.66667 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/140174 A2, 2007 ;
Location in patent: Page/Page column 45 ;
反应条件
triethylamine
T=0°C; 2 h;
参考文献
Chen, Jian; Lin, Guo-Qiang; Wang, Zhi-Min; Liu, Han-Quan
Synlett, 2002 , # 8 p. 1265 - 1268
反应条件
triethylamine in tetrahydrofuran
T=0°C; 1.5 h;
参考文献
Moeller, Lena; Hess, Christian; Palecek, Jiri; Su, Yi; Haverich, Axel; Kirschning, Andreas; Draeger, Gerald
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 270 - 277
反应条件
1: potassium iodide / toluene / 48 h / 20 °C
2: triethylamine / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Moeller, Lena; Hess, Christian; Palecek, Jiri; Su, Yi; Haverich, Axel; Kirschning, Andreas; Draeger, Gerald
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 270 - 277
