1: trans 4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexylamine dihydrochloride With triethylamine in dichloromethane T=20 - 25°C; 1 h; 2: bis(trichloromethyl) carbonate in dichloromethane T=-10 - -5°C; 1 h; 3: dimethyl amine in dichloromethane; isopropyl alcohol T=-10 - 0°C; 0.5 h;

in dichloromethane; isopropyl alcohol T=-10 - 0°C; 0.5 h;

in dichloromethane T=20°C; 18 h;

1: diisobutylaluminium hydride / toluene / -78 °C / |Inert atmosphere 2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 3: trifluoroacetic acid / dichloromethane / 20 °C 4: dichloromethane / 18 h / 20 °C View Scheme

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 20 °C 3: dichloromethane / 18 h / 20 °C View Scheme

1: hydrogenchloride / water / 2 h / |Reflux 2: triethylamine / dichloromethane / 20 °C 3: diisobutylaluminium hydride / toluene / -78 °C / |Inert atmosphere 4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 5: trifluoroacetic acid / dichloromethane / 20 °C 6: dichloromethane / 18 h / 20 °C View Scheme

1: palladium 10 on activated carbon; hydrogen / water / 72 h / 20 °C / 3102.97 Torr 2: hydrogenchloride / water / 2 h / |Reflux 3: triethylamine / dichloromethane / 20 °C 4: diisobutylaluminium hydride / toluene / -78 °C / |Inert atmosphere 5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 6: trifluoroacetic acid / dichloromethane / 20 °C 7: dichloromethane / 18 h / 20 °C View Scheme

1: triethylamine / dichloromethane / 20 °C 2: diisobutylaluminium hydride / toluene / -78 °C / |Inert atmosphere 3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 20 °C 5: dichloromethane / 18 h / 20 °C View Scheme

hydrogenchloride in methanol; water T=60 - 75°C; 4 h; Product distribution / selectivity;