1-[3-(4-溴-1-甲基-1H-吡唑-5-基)-4-甲氧基苯基]-3-(2,4-二氟苯基)脲合成路线 （共 3 条）
反应条件
in toluene
T=12.9 - 19°C; 4.91667 h;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/103011 A1, 2005 ;
Location in patent: Page/Page column 48 ;
WO 2005/103011 A1
反应条件
in acetonitrile
T=-10°C; 1 h; Inert atmosphere;
参考文献
ARENA PHARMACEUTICALS, INC.; CARLOS, Marlon V.; DONG, Weitong; MACIAS, Mark; SATO, Suzanne Michiko; SILVEY, Gary
Patent: WO2010/62321 A1, 2010 ;
Location in patent: Page/Page column 75-76 ;
反应条件
1: 3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenylamine With N-ethyl-N,N-diisopropylamine in methanol
T=20°C; 0.5 h;
2: 2,4-difluorophenyl isocyanate in methanol
T=20 - 80°C; 3 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2006/81335 A2, 2006 ;
Location in patent: Page/Page column 36-38 ;
WO 2006/081335 A2
