1-甲基螺[4H-3,1-苯并恶嗪-4,4'-哌啶]-2(1H)-酮合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane
2 h; Ambient temperature;
参考文献
Clark; Caroon; Kluge; Repke; Roszkowski; Strosberg; Baker; Bitter; Okada
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 657 - 661
反应条件
1: 1.) t-bytyllithium, 2.) t-butoxide / 1.) pentane, THF, a) -70 deg, 0.5 h, b) -20 deg, 2.5 h, 2.) THF, a) from -70 deg to RT, 4 h, b) RT, 16 h
2: 1.) NaH / 1.) DMF, 20 deg, 0.5 h, 2.) DMF, 20 deg, 1 h
3: 78 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Clark; Caroon; Kluge; Repke; Roszkowski; Strosberg; Baker; Bitter; Okada
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 657 - 661
反应条件
1: 1.) t-bytyllithium, 2.) t-butoxide / 1.) pentane, THF, a) -70 deg, 0.5 h, b) -20 deg, 2.5 h, 2.) THF, a) from -70 deg to RT, 4 h, b) RT, 16 h
2: 1.) NaH / 1.) DMF, 20 deg, 0.5 h, 2.) DMF, 20 deg, 1 h
3: 78 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Clark; Caroon; Kluge; Repke; Roszkowski; Strosberg; Baker; Bitter; Okada
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 657 - 661
反应条件
1: 1.) NaH / 1.) DMF, 20 deg, 0.5 h, 2.) DMF, 20 deg, 1 h
2: 78 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Clark; Caroon; Kluge; Repke; Roszkowski; Strosberg; Baker; Bitter; Okada
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 657 - 661
