5-氯-2-甲基-1-苯基-1H-苯并咪唑合成路线 （共 4 条）
反应条件
1: With potassium phosphate; N-methyl-1,2-ethanediamine; copper(l) iodide in toluene
T=100°C; 18 h;
2: With water in toluene
3: With iron; sodium hydrogencarbonate; acetic acid
Product distribution / selectivity; more than 3 stages;
参考文献
SANOFI-AVENTIS
Patent: WO2009/413 A1, 2008 ;
Location in patent: Page/Page column 27 ;
反应条件
1: With palladium (II) trifluoroacetate; caesium carbonate; (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl in toluene
T=80°C; 18 h; Inert atmosphere;
2: With iron; acetic acid in toluene
0.5 h; Reflux;
参考文献
Alonso, Jorge; Halland, Nis; Nazare, Marc; R'Kyek, Omar; Urmann, Matthias; Lindenschmidt, Andreas
European Journal of Organic Chemistry, 2011 , # 2 p. 234 - 237
反应条件
1: With iron; acetic acid
0.5 h; Heating / reflux;
2: With sodium hydrogencarbonate in water
Product distribution / selectivity;
参考文献
sanofi-aventis
Patent: EP1878724 A1, 2008 ;
Location in patent: Page/Page column 13-14 ;
参考文献
Eastman Kodak Co.
Patent: US2739149 , 1953 ;
