5-溴苯并呋喃-2-羧酸乙酯合成路线 （共 9 条）
反应条件
P(MeNCH2CH2)3N in ethanol T=70°C; 3 h;
参考文献
D'Sa, Bosco A.; Kisanga, Philip; Verkade, John G.
Synlett, 2001 , # 5 p. 670 - 672
反应条件
sulfuric acid in ethanol
参考文献
Laboratorios Menarini S.A.
Patent: US5990142 A1, 1999 ;
反应条件
potassium carbonate in butanone 72 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26871 A1, 2004 ;
Location in patent: Page 47 ;
WO 2004/026871 A1
反应条件
sodium carbonate in N,N-dimethyl-formamide
参考文献
US2004/209865 A1, ;
US 20040209865 A1
参考文献
US2001/56100 A1, ;
US 20010056100 A1
反应条件
1.1: KOH / methanol / 0.5 h / 50 °C 1.2: dimethylformamide; methanol / 0 - 25 °C 2.1: 98 percent / P(MeNCH2CH2)3N / ethanol / 3 h / 70 °C View Scheme
参考文献
Synlett, , # 5 p. 670 - 672
反应条件
potassium carbonate Cyclization;
参考文献
Owen; Nicholls; Smith; Whomsley
The Journal of pharmacy and pharmacology, 1999 , vol. 51, # 4 p. 427 - 433
反应条件
1: 79.3 percent / Br2 / CS2 / 50 °C 2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 2 h 3: 1.) NaOEt, 2.) H2SO4 / 1.) EtOH, reflux, 3 h, 2.) EtOH, reflux, 1 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 2 p. 445 - 459
反应条件
1: With sodium tetrahydroborate in ethanol T=0°C; 1 h; 2: With hydrogenchloride; water pH=2;
参考文献
Ladouceur, Gaetan H.; Schoen, William R.; Burke, Michael J.
Patent: US2003/195352 A1, 2003 ;
Location in patent: Page/Page column 31 ;
