2-甲酰基苯并呋喃-5-甲腈合成路线 （共 10 条）
反应条件
nitric acid
T=60°C; 0.0166667 h;
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 80 percent / N-methylpyrrolidine / 0.5 h / Heating
2: 95 percent / 1) NaHCO3, CaI2, NaBH4; 2) CaI2, NaBH4 / tetrahydrofuran / 1) 0 to 5 deg C, 1 h; 2) room temp., 2 h
3: 95 percent / HNO3 / 0.02 h / 60 °C
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 95 percent / conc. H2SO4 / 15 h / Heating
2: 80 percent / N-methylpyrrolidine / 0.5 h / Heating
3: 95 percent / 1) NaHCO3, CaI2, NaBH4; 2) CaI2, NaBH4 / tetrahydrofuran / 1) 0 to 5 deg C, 1 h; 2) room temp., 2 h
4: 95 percent / HNO3 / 0.02 h / 60 °C
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 95 percent / 1) NaHCO3, CaI2, NaBH4; 2) CaI2, NaBH4 / tetrahydrofuran / 1) 0 to 5 deg C, 1 h; 2) room temp., 2 h
2: 95 percent / HNO3 / 0.02 h / 60 °C
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 69 percent / 1) benzene, 90 min, reflux; 2) ethanol, 1 h
2: 89 percent / CH3ONa / methanol / 1 h
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 69 percent / 1) benzene, 90 min, reflux; 2) ethanol, 1 h
2: 78 percent / CH3ONa / methanol / 1 h
3: 97 percent
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 69 percent / 1) benzene, 90 min, reflux; 2) ethanol, 1 h
2: 89 percent / CH3ONa / methanol / 1 h
4: 2 N HCl / 1 h
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 69 percent / 1) benzene, 90 min, reflux; 2) ethanol, 1 h
2: 78 percent / CH3ONa / methanol / 1 h
3: 1) HCl (g); 2) NH3 (g) / 1) chloroform, ethanol, 7 d; 2) ether, ethanol, 7 d
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 69 percent / 1) benzene, 90 min, reflux; 2) ethanol, 1 h
2: 78 percent / CH3ONa / methanol / 1 h
3: 2 N HCl
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 69 percent / 1) benzene, 90 min, reflux; 2) ethanol, 1 h
2: 58 percent / 1) benzene, 3 h, reflux; 2) ethanol, 1 h
3: 69 percent / CH3ONa / methanol / 1 h
4: 1) HCl (g); 2) NH3 (g) / 1) chloroform, ethanol, 7 d; 2) ether, ethanol, 7 d
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
