sodium hydride in toluene; tert-butyl alcohol
T=100°C; 3 h;
参考文献
Bunnage, Mark E.; Davies, Stephen G.; Parkin, Richard M.; Roberts, Paul M.; Smith, Andrew D.; Withey, Jonathan M.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3337 - 3354
1: 89 percent / N,N-dimethylaniline / diethyl ether / 20 h / 20 °C
2: 84 percent / NaH / toluene; 2-methyl-propan-2-ol / 3 h / 100 °C
View Scheme
参考文献
Bunnage, Mark E.; Davies, Stephen G.; Parkin, Richard M.; Roberts, Paul M.; Smith, Andrew D.; Withey, Jonathan M.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3337 - 3354
1.1: NaH / tetrahydrofuran / 0.33 h
1.2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.3: 92 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 93 percent / NaBH4 / ethanol / 1 h / 0 °C
3.1: 87 percent / PPh3; DIAD / tetrahydrofuran / 20 °C
View Scheme
参考文献
Bunnage, Mark E.; Davies, Stephen G.; Parkin, Richard M.; Roberts, Paul M.; Smith, Andrew D.; Withey, Jonathan M.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3337 - 3354
