2-氯-1-[[2-(三甲基锡)乙氧基]甲基]-苯并咪唑合成路线 （共 2 条）
反应条件
1: 2-Chloro-1H-1,3-benzimidazole With sodium hydride in N,N-dimethyl-formamide
T=5 - 10°C; 2.5 h;
2: trimethylsilyl ethoxymethyl chloride in N,N-dimethyl-formamide
T=20°C; 18.0833 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/12296 A1, 2005 ;
Location in patent: Page/Page column 78-79 ;
WO 2005/012296 A1
反应条件
1: 2-Chloro-1H-1,3-benzimidazole With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
2: trimethylsilyl ethoxymethyl chloride in N,N-dimethyl-formamide
T=0 - 20°C; 16 h;
参考文献
DECODE CHEMISTRY, INC.
Patent: US2007/66820 A1, 2007 ;
Location in patent: Page/Page column 61-62 ;
US 20070066820 A1
