3-羟基-4,4-二甲氧基哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C 1.2: 0 - 20 °C 2.1: hydrogenchloride / 1,4-dioxane / 50 °C 2.2: pH 10 2.3: 4 h View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; WITTY, David R.; NORTON, David; TIERNEY, Jason Paul; LORTHIOIR, Ghislaine; SIME, Mairi; PHILPOTT, Karen Louise
Patent: WO2012/80735 A1, 2012 ;
WO 2012/080735 A1
反应条件
iodine; potassium hydroxide
T=0 - 20°C; 2.5 h;
参考文献
Surmont, Riccardo; Verniest, Guido; De Weweire, Arvid; Thuring, Jan Willem; Macdonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
Synlett, 2009 , # 12 p. 1933 - 1936
反应条件
sodium iodide in methanol
T=30°C; Electrochemical reaction;
参考文献
Elinson, Michail N.; Dorofeev, Alexander S.; Feducovich, Sergey K.; Nasybullin, Ruslan F.; Litvin, Evgeny F.; Kopyshev, Mikhail V.; Nikishin, Gennady I.
Tetrahedron, 2006 , vol. 62, # 34 p. 8021 - 8028
反应条件
acetone; toluene-4-sulfonic acid
T=20°C; 72 h;
参考文献
PFIZER INC.; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton, Jr.
Patent: WO2012/69948 A1, 2012 ;
Location in patent: Page/Page column 74 ;
