2-(5-甲氧基)苯酚4-(N-苄氧羰基)哌啶基甲酮合成路线 （共 6 条）
反应条件
sodium hydrogencarbonate in dichloromethane
参考文献
Hoechst-Roussel Pharmaceuticals
Patent: US4355037 A1, 1982 ;
反应条件
sodium hydrogencarbonate in dichloromethane
1.5 h; Ambient temperature;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: 68 percent / 6 N aq. HCl / 6 h / Heating
2: 76 percent / NaHCO3 / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: AlCl3 / 2 h / Heating
2: 68 percent / 6 N aq. HCl / 6 h / Heating
3: 76 percent / NaHCO3 / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 40 - 65 °C
2: AlCl3 / 2 h / Heating
3: 68 percent / 6 N aq. HCl / 6 h / Heating
4: 76 percent / NaHCO3 / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: AlCl3 / 2 h / Heating
2: 68 percent / 6 N aq. HCl / 6 h / Heating
3: 76 percent / NaHCO3 / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
