1-[4-(5-氟-1,2-苯并异恶唑-3-基)-1-哌啶基]-乙酮合成路线 (共 3 条)
反应条件
hydrogenchloride 6 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769
反应条件
sodium hydride in N,N-dimethyl-formamide
16 h; Ambient temperature; Yield given;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1: 1.5 h / 60 °C
2: NaH / dimethylformamide / 16 h / Ambient temperature
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769