6-氟-3-哌啶-4-基-1,2-苯并异唑盐酸盐合成路线 （共 28 条）
反应条件
2-chloroethoxycarbonyl chloride; triethylamine in 1,2-dichloro-ethane T=0 - 20°C;
参考文献
WO2008/108957 A2, ;
Page/Page column 36 ;
反应条件
hydrogenchloride in ethanol 3 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769
反应条件
1: NaH / dimethylformamide / 4 h / 70 - 75 °C 2: aq. HCl / ethanol / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769
反应条件
1: AlCl3, aluminium chloride 2: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 3: potassium hydroxide / isopropyl alcohol; water 4: hydrogenchloride View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
反应条件
1: acetic anhydride 2: thionyl chloride 3: AlCl3, aluminium chloride 4: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 5: potassium hydroxide / isopropyl alcohol; water 6: hydrogenchloride View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
反应条件
1: thionyl chloride 2: AlCl3, aluminium chloride 3: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 4: potassium hydroxide / isopropyl alcohol; water 5: hydrogenchloride View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
反应条件
1: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 2: potassium hydroxide / isopropyl alcohol; water 3: hydrogenchloride View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
反应条件
sodium hydroxide in water; isobutyl methylketone 0.0833333 - 0.166667 h; Product distribution / selectivity;
参考文献
MSN LABORATORIES LIMITED
Patent: US2011/293889 A1, 2011 ;
反应条件
potassium iodide; sodium carbonate
反应条件
sodium hydroxide in water
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Revu
Patent: WO2010/4578 A2, 2010 ;
Location in patent: Page/Page column 22-23 ;
