1-甲酰基-哌啶-4-羧酸合成路线 （共 8 条）
反应条件
1: formic acid With acetic anhydride T=55 - 60°C; 1 h; 2: 4-piperidinylcarboxylic acid T=0 - 5°C; 14 h;
参考文献
Basappa; Mantelingu; Sadashiva; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1954 - 1957
反应条件
16 h; Ambient temperature;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 3115,3118; engl. Ausg. S. 3146, 3148
反应条件
1.1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C 2.1: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling 3.1: hydroxylamine sulfate; potassium hydroxide / methanol / 8 h / Heating 3.2: water / methanol / 2 h / Heating View Scheme
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
1: thionyl chloride 2: AlCl3, aluminium chloride 3: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 4: potassium hydroxide / isopropyl alcohol; water 5: hydrogenchloride View Scheme
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C
2: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling
View Scheme
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
thionyl chloride; N,N-dimethyl-formamide
3 h; Ambient temperature;
参考文献
Hoechst-Roussel Pharmaceuticals
Patent: US4355037 A1, 1982 ;
反应条件
aluminium trichloride; thionyl chloride in dichloromethane; N,N-dimethyl-formamide
Friedel-Crafts reaction;
参考文献
Rangappa, Kanchugarakoppal S.; Basappa
Journal of Physical Organic Chemistry, 2005 , vol. 18, # 8 p. 773 - 778
