1-甲酰基-哌啶-4-羰酰氯合成路线 （共 5 条）
反应条件
1.1: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling 2.1: hydroxylamine sulfate; potassium hydroxide / methanol / 8 h / Heating 2.2: water / methanol / 2 h / Heating View Scheme
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
1: AlCl3, aluminium chloride 2: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 3: potassium hydroxide / isopropyl alcohol; water 4: hydrogenchloride View Scheme
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
thionyl chloride; N,N-dimethyl-formamide
3 h; Ambient temperature;
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
反应条件
1.1: acetic anhydride / 1 h / 55 - 60 °C
1.2: 95 percent / 14 h / 0 - 5 °C
2.1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C
View Scheme
参考文献
Basappa; Mantelingu; Sadashiva; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1954 - 1957
反应条件
aluminium trichloride in dichloromethane
Friedel-Crafts acylation; 4 h; cooling;
参考文献
Basappa; Mantelingu; Sadashiva; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 1954 - 1957
