6-氟-3-(哌啶-4-基)苯并[D]异恶唑合成路线 （共 25 条）
反应条件
water; sodium hydroxide 4 h; Reflux;
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
potassium hydroxide in water
反应条件
sodium hydroxide in water; isobutyl methylketone 0.0833333 - 0.166667 h; Product distribution / selectivity;
参考文献
WO2007/93870 A2, ;
Page/Page column 7-9 ;
反应条件
1: With potassium hydroxide; hydroxylammonium sulfate in methanol 8 h; Heating; 2: With water in methanol 2 h; Heating;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 9 p. 1954 - 1957
反应条件
1.1: acetic anhydride / 1 h / 55 - 60 °C 1.2: 95 percent / 14 h / 0 - 5 °C 2.1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C 3.1: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling 4.1: hydroxylamine sulfate; potassium hydroxide / methanol / 8 h / Heating 4.2: water / methanol / 2 h / Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 9 p. 1954 - 1957
反应条件
1.1: thionyl chloride / CH2Cl2 / 3 h / 35 - 40 °C 2.1: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling 3.1: hydroxylamine sulfate; potassium hydroxide / methanol / 8 h / Heating 3.2: water / methanol / 2 h / Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 9 p. 1954 - 1957
反应条件
1.1: 88 percent / AlCl3 / CH2Cl2 / 4 h / cooling 2.1: hydroxylamine sulfate; potassium hydroxide / methanol / 8 h / Heating 2.2: water / methanol / 2 h / Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 9 p. 1954 - 1957
反应条件
1: hydrogenchloride 2: sodium hydroxide / dichloromethane / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
反应条件
1: potassium hydroxide / isopropyl alcohol; water 2: hydrogenchloride 3: sodium hydroxide / dichloromethane / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
反应条件
1: ammonium chloride / dichloromethane / 3 h / 20 °C / Reflux 2: hydrogenchloride / water / 5 h / Reflux 3: hydroxylamine hydrochloride; 2-(dimethylamino)-ethanol / ethanol / 3 h / 20 °C / Reflux 4: sodium hydroxide; water / 4 h / Reflux View Scheme
