(1-苄基-4-苯基哌啶-4-基)甲胺合成路线 (共 5 条)
反应条件
1: With lithium aluminium tetrahydride in diethyl ether
T=0 - 25°C;
2: With sodium hydrogencarbonate in diethyl ether
参考文献
SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.
Patent: WO2008/124582 A1, 2008 ;
Location in patent: Page/Page column 131-132 ;
WO 2008/124582 A1
反应条件
1: 80 percent
2: 55 percent / LiAlH4 / diethyl ether
View Scheme
参考文献
Rehse; Werner
Archiv der Pharmazie, 1986 , vol. 319, # 6 p. 505 - 515
反应条件
1: 80 percent
2: 55 percent / LiAlH4 / diethyl ether
View Scheme
参考文献
Rehse; Werner
Archiv der Pharmazie, 1986 , vol. 319, # 6 p. 505 - 515
参考文献
Sterling Drug Inc.
Patent: US2538107 , 1946 ;
反应条件
pyridine; diethyl ether
参考文献
Kwartler; Lucas
Journal of the American Chemical Society, 1947 , vol. 69, p. 2582,2585