5-羟基-1-甲基咪唑啉-2,4-二酮合成路线 （共 8 条）
反应条件
iodic acid T=60°C; 0.5 h;
参考文献
Ienaga, Kazuharu; Nakamura, Ko; Ishii, Akira; Taga, Tooru; Miwa, Yoshihisa; Yoneda, Fumio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1153 - 1156
反应条件
(+/-)-2-Ethyloxirane; water
T=0 - 20°C; 1 h; Product distribution / selectivity;
参考文献
Nippon Zoki Pharmaceutical Co. Ltd.
Patent: EP1493734 A1, 2005 ;
Location in patent: Page 7 ;
反应条件
acetic acid in methanol
参考文献
Nippon Zoki Pharmaceutical Co., Ltd.
Patent: US4647574 A1, 1987 ;
反应条件
oxygen; ozone in water
T=37°C; 2 h;
参考文献
Matsui, Masaki; Nakazumi, Hiroyuki; Kamiya, Kazusaki; Yatome, Chizuko; Shibata, Katsuyoshi; Muramatsu, Hiroshige
Chemistry Letters, 1989 , p. 723 - 724
反应条件
dimethylaminopyidine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile
T=0°C; 2 h; 1) 0 deg C, 2 h 2) rt, 3 h;
参考文献
Ienaga, Kazuharu; Nakamura, Ko; Ishii, Akira; Taga, Tooru; Miwa, Yoshihisa; Yoneda, Fumio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1153 - 1156
反应条件
acetic acid in water
T=100°C; 2 h;
参考文献
Bayer Aktiengesellschaft
Patent: US6365752 B1, 2002 ;
Location in patent: Page column 13-14 ;
反应条件
sulfuric acid
0.666667 h; Ambient temperature; Yield given;
参考文献
Ienaga, Kazuharu; Nakamura, Ko; Ishii, Akira; Taga, Tooru; Miwa, Yoshihisa; Yoneda, Fumio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1153 - 1156
反应条件
triethylamine in methanol; water
参考文献
NIPPON ZOKI PHARMACEUTICAL CO. LTD.
Patent: EP160618 B1, 1991 ;
