5-溴-3-氯噻吩-2-羧酸合成路线 （共 3 条）
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: With ethylene dibromide in tetrahydrofuran; hexane
T=-78 - 25°C; 1.5 h;
参考文献
SCHERING CORPORATION; WU, Wen-Lian; BURNETT, Duane A.; STAMFORD, Andrew W.; CUMMING, Jared N.; BENNETT, Chad Edward; GILBERT, Eric J.; PENG, Xuanjia; SCOTT, Jack D.; YU, Younong
Patent: WO2012/139425 A1, 2012 ;
Location in patent: Page/Page column 119 ;
WO 2012/139425 A1
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78 - 20°C; 4 h; Inert atmosphere; Further stages;
参考文献
MERCK SHARP and DOHME CORP.; WU, Wen-Lian; BURNETT, Duane, A.; STAMFORD, Andrew; CUMMING, Jared, N.; ASBEROM, Theodros; BENNETT, Chad; SASISKUMAR, Thavalakulamgara, K.; SCOTT, Jack, D.
Patent: WO2013/28670 A1, 2013 ;
Location in patent: Page/Page column 96 ;
反应条件
1.1: sodium hydroxide; water / methanol / 2 h / 0 - 25 °C
2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 1.5 h / -78 - 25 °C
View Scheme
参考文献
SCHERING CORPORATION; WU, Wen-Lian; BURNETT, Duane A.; STAMFORD, Andrew W.; CUMMING, Jared N.; BENNETT, Chad Edward; GILBERT, Eric J.; PENG, Xuanjia; SCOTT, Jack D.; YU, Younong
Patent: WO2012/139425 A1, 2012 ;
WO 2012/139425 A1
