5-溴-2-氯-n-甲氧基-n-甲基苯甲酰胺合成路线 （共 4 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-15 - -10°C; 1 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
EP1845095 A1, ;
Page/Page column 36-37 ;
反应条件
1: N-methyl-O-methylhydroxyamine hydrochloride With triethylamine in dichloromethane
16 h;
2: 5-bromo-2-chloro-benzoic acid With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride in dichloromethane
参考文献
JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; Yang, Fanglong; Tang, Peng Cho; Dong, Qing; Tu, Wangyang; Fan, Jiang; Guan, Dongliang; Shen, Guangyuan; Wang, Yang; Yuan, Jijun; Zhang, Limin
Patent: US2013/130997 A1, 2013 ;
Location in patent: Paragraph 0149 ;
反应条件
triethylamine in chloroform
T=0°C; 0.5 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.
Patent: WO2007/136116 A2, 2007 ;
Location in patent: Page/Page column 91-92 ;
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=20°C; 64 h;
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US2008/27014 A1, 2008 ;
Location in patent: Page/Page column 39-40 ;
