(7-溴-1-乙基-1H-咪唑并[4,5-c]吡啶-2-基)乙腈合成路线 （共 4 条）
反应条件
T=190°C; 1 h; Inert atmosphere;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/46678 A1, 2005 ;
Location in patent: Page/Page column 78; 85 ;
WO 2005/046678 A1
反应条件
1: aq. sodium dithionite / ethanol / 60 °C
2: 190 °C
View Scheme
参考文献
Bamford, Mark J.; Bailey, Nicholas; Davies, Susannah; Dean, David K.; Francis, Leann; Panchal, Terence A.; Parr, Christopher A.; Sehmi, Sanjeet; Steadman, Jon G.; Takle, Andrew K.; Townsend, James T.; Wilson, David M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3407 - 3411
反应条件
1: 43 percent / Br2; acetic acid / 100 °C
2: aq. sodium dithionite / ethanol / 60 °C
3: 190 °C
View Scheme
参考文献
Bamford, Mark J.; Bailey, Nicholas; Davies, Susannah; Dean, David K.; Francis, Leann; Panchal, Terence A.; Parr, Christopher A.; Sehmi, Sanjeet; Steadman, Jon G.; Takle, Andrew K.; Townsend, James T.; Wilson, David M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3407 - 3411
反应条件
1: With sodium nitrite in methanol
2 h;
2: With sodium hydroxide; hydroxylamine in methanol; water
T=90°C; pH=12; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/46678 A1, 2005 ;
Location in patent: Page/Page column 78; 85 ;
WO 2005/046678 A1
