2-(7-溴-4-氯-1-乙基-1H-咪唑并[4,5-c]吡啶-2-基)乙腈合成路线 （共 7 条）
反应条件
acetic acid
T=100°C; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/58850 A2, 2007 ;
Location in patent: Page/Page column 39 ;
WO 2007/058850 A2
反应条件
1: hydrogenchloride; water
2: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
3: acetic acid
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
2: acetic acid
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: water; tetrahydrofuran
2: hydrogenchloride; water
3: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
4: acetic acid
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
hydrogenchloride; sodium nitrite in water
T=20°C; 0.833333 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/11700 A1, 2005 ;
Location in patent: Page/Page column 88 ;
WO 2005/011700 A1
反应条件
1: sodium nitrite
2: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: sodium nitrite
2: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol
3: hydrogenchloride; sodium hydroxide; dihydrogen peroxide / ethyl acetate; toluene; water; isopropylmagnesium chloride; tetrahydrofuran
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
