3-溴-N-((1-乙基-2-吡咯烷基)甲基)-2-羟基-6-甲氧基苯甲酰胺合成路线 （共 4 条）
反应条件
hydrogenchloride; boron tribromide in dichloromethane
T=20°C; 0.5 h;
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
反应条件
1: SOCl2, DMF / toluene / 1 h / 65 °C
2: 51 percent / CHCl3 / 0.5 h / 25 °C
3: 51 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
4: 76 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
反应条件
1: 51 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
2: 76 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
反应条件
1: 51 percent / CHCl3 / 0.5 h / 25 °C
2: 51 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
3: 76 percent / 3N HCl, BBr3 / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
