1-苄基-1-氮杂-12-冠-4合成路线 （共 8 条）
参考文献
Arnold, Kristin A.; Mallen, Jesus; Trafton, John E.; White, Banita D.; Fronczek, Frank R.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5652 - 5657
反应条件
palladium in ethanol
参考文献
The President and Trustees of the Miami University
Patent: US4659815 A1, 1987 ;
反应条件
sodium carbonate in acetonitrile
18 h; Heating;
参考文献
Schultz,R.A.; White,B.D.; Dishong,D.M.
Journal of the American Chemical Society, 1985 , vol. 107, p. 6659
反应条件
tetrabutylammomium bromide; lithium chloride; sodium hydroxide in water; benzene
T=70°C; 25 h; Reagent/catalyst;
参考文献
Luk'yanenko; Basok; Kulygina, E. Yu.; Bogashchenko, T. Yu.; Yakovenko
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 10 p. 1345 - 1352
Zh. Org. Khim., 2012 , vol. 48, # 10 p. 1350 - 1357,8
反应条件
1: NaI / acetone / 70 h / Heating
2: 54 percent / Na2CO3 / acetonitrile / 18 h / Heating
View Scheme
参考文献
Calverley, Martin J.; Dale, Johannes
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 4 p. 241 - 248
反应条件
1: 83 percent / thionyl chloride / pyridine / Ambient temperature
2: NaI / acetone / 70 h / Heating
3: 54 percent / Na2CO3 / acetonitrile / 18 h / Heating
View Scheme
参考文献
Calverley, Martin J.; Dale, Johannes
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 4 p. 241 - 248
反应条件
1: 85 percent / H2 / Pd/C / acetic acid / 15 h / 60 °C / 2280 Torr
2: 1.) K2CO3, 2.) LiAlH4 / 1.) THF, 2.) RT, 18 h
View Scheme
参考文献
Calverley, Martin J.; Dale, Johannes
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 4 p. 241 - 248
反应条件
1: 85 percent / H2 / Pd-C
2: NEt3 / CH2Cl2
3: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Calverley, Martin J.; Dale, Johannes
Journal of the Chemical Society, Chemical Communications, 1981 , # 14 p. 684 - 686
